Dextromethorphan HBr USP32

M A T E R I A L S A F E T Y D A T A S H E ETSECTION 1. − − − − − − − − − CHEMICAL IDENTIFICATION− − − − − − − − − − CATALOG #: D115 NAME: DEXTROMETHORPHAN HBR SECTION 2. − − − − − COMPOSITION/INFORMATION ON INGREDIENTS − − − − − − CAS #: 125−69−9 MF: C18H25NO EC NO: 204−750−1 SYNONYMS ANTUSSAN * DEMORPHAN * DEXTROMETHORPHAN BROMIDE * DEXTROMETHORPHAN HYDROBROMIDE * DEXTROMETORPHAN HYDROBROMIDE * DORMETHAN * MEDICON * METHORATE HYDROBROMIDE * D−METHORPHAN HYDROBROMIDE * D−3−METHOXY−N− METHYLMORPHINAN HYDROBROMIDE * METRORAT * 9−ALPHA,13−ALPHA,14−ALPHA− MORPHINAN, 3−METHOXY−17−METHYL−, HYDROBROMIDE * RO 1−5470/5 * ROMILAR * ROMILAR HYDROBROMIDE * TUSILAN * TUSSADE * SECTION 3. − − − − − − − − − − HAZARDS IDENTIFICATION − − − − − − − − −LABEL PRECAUTIONARY STATEMENTS TOXIC (USA) HARMFUL (EU) HARMFUL IF SWALLOWED. TARGET ORGAN(S): LUNGS WEAR SUITABLE PROTECTIVE CLOTHING. SECTION 4. − − − − − − − − − − FIRST−AID MEASURES− − − − − − − − − − − IF SWALLOWED, WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS. CALL A PHYSICIAN.IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN. IN CASE OF SKIN CONTACT, FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. REMOVE CONTAMINATED CLOTHING AND SHOES. CALL A PHYSICIAN. IN CASE OF CONTACT WITH EYES, FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING THE EYELIDS WITH FINGERS. CALL A PHYSICIAN. SECTION 5. − − − − − − − − − FIRE FIGHTING MEASURES − − − − − − − − − − EXTINGUISHING MEDIA WATER SPRAY. CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE FOAM. SPECIAL FIREFIGHTING PROCEDURES WEAR SELF−CONTAINED BREATHING APPARATUS AND PROTECTIVE CLOTHING TO PREVENT CONTACT WITH SKIN AND EYES. UNUSUAL FIRE AND EXPLOSIONS HAZARDS EMITS TOXIC FUMES UNDER FIRE CONDITIONS. SECTION 6. − − − − − − − − ACCIDENTAL RELEASE MEASURES− − − − − − − − − WEAR SELF−CONTAINED BREATHING APPARATUS, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SWEEP UP, PLACE IN A BAG AND HOLD FOR WASTE DISPOSAL. AVOID RAISING DUST. VENTILATE AREA AND WASH SPILL SITE AFTER MATERIAL PICKUP IS COMPLETE. EVACUATE AREA. SECTION 7. − − − − − − − − − − HANDLING AND STORAGE− − − − − − − − − − − REFER TO SECTION 8. SECTION 8. − − − − − − EXPOSURE CONTROLS/PERSONAL PROTECTION− − − − − − SAFETY SHOWER AND EYE BATH. MECHANICAL EXHAUST REQUIRED. WASH THOROUGHLY AFTER HANDLING. DO NOT BREATHE DUST. AVOID CONTACT WITH EYES, SKIN AND CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE. NIOSH/MSHA−APPROVED RESPIRATOR. COMPATIBLE CHEMICAL−RESISTANT GLOVES. CHEMICAL SAFETY GOGGLES. STORE IN A COOL DRY PLACE. KEEP TIGHTLY CLOSED. SECTION 9. − − − − − − − PHYSICAL AND CHEMICAL PROPERTIES − − − − − − − APPEARANCE AND ODOR SOLID. PHYSICAL PROPERTIES MELTING POINT: 122 − 124 C SECTION 10. − − − − − − − − −STABILITY AND REACTIVITY − − − − − − − − − STABILITY STABLE. HAZARDOUS COMBUSTION OR DECOMPOSITION PRODUCTS CARBON MONOXIDE, CARBON DIOXIDE HYDROGEN BROMIDE GAS NITROGEN OXIDES HAZARDOUS POLYMERIZATION WILL NOT OCCUR. SECTION 11. − − − − − − − − − TOXICOLOGICAL INFORMATION − ACUTE EFFECTS MAY CAUSE SKIN IRRITATION. MAY BE HARMFUL IF ABSORBED THROUGH THE SKIN. MAY CAUSE EYE IRRITATION. MAY BE HARMFUL IF INHALED. MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND UPPER RESPIRATORY TRACT. HARMFUL IF SWALLOWED. CHRONIC EFFECTS TARGET ORGAN(S): LUNGS RTECS #: QD0222000 MORPHINAN, 3−METHOXY−N−METHYL−, HYDROBROMIDE, (+)− SECTION 12. − − − − − − − − − ECOLOGICAL INFORMATION − −----------------- DATA NOT YET AVAILABLE. SECTION 13. − − − − − − − − − DISPOSAL CONSIDERATIONS − − − − − − − − − CONTACT A LICENSED PROFESSIONAL WASTE DISPOSAL SERVICE TO DISPOSE OF THIS MATERIAL. DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL REGULATIONS. SECTION 14. − − − − − − − − − − TRANSPORT INFORMATION − − − − − − − − − CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION INFORMATION. SECTION 15. − − − − − − − − − REGULATORY INFORMATION − − − − − − − − − − EUROPEAN INFORMATION HARMFUL R 22 HARMFUL IF SWALLOWED. S 36/37 WEAR SUITABLE PROTECTIVE CLOTHING AND GLOVES. REVIEWS, STANDARDS, AND REGULATIONS OEL=MAK NOHS 1974: HZD 80399; NIS 4; TNF 262; NOS 9; TNE 3682 NOES 1983: HZD 80399; NIS 3; TNF 213; NOS 3; TNE 1826; TFE 1049